SCO2 Mediates Oxidative Stress-Induced Glycolysis to Oxidative Phosphorylation Switch in Hematopoietic Stem Cells.

Abstract

Fanconi anemia (FA) is an inherited bone marrow (BM) failure syndrome, presumably resulting from defects in hematopoietic stem cells (HSCs). Normal HSCs depend more on glycolysis than on oxidative phosphorylation (OXPHOS) for energy production. Here, we show that FA HSCs are more sensitive to the respiration inhibitor NaN3 treatment than to glycolytic… (More)
DOI: 10.1002/stem.2260

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@article{Du2016SCO2MO, title={SCO2 Mediates Oxidative Stress-Induced Glycolysis to Oxidative Phosphorylation Switch in Hematopoietic Stem Cells.}, author={Wei Du and Surya Amarachintha and Andrew F. Wilson and Qishen Pang}, journal={Stem cells}, year={2016}, volume={34 4}, pages={960-71} }