SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts.

@article{Deuse2015SCNTderivedEW,
  title={SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts.},
  author={Tobias Deuse and Dong Wang and Mandy Stubbendorff and Ryo Itagaki and Antje Grabosch and Laura C. Greaves and Malik Alawi and Anne Gr{\"u}newald and Xiaomeng Hu and Xiaoqin Hua and J. W. ten Velden and Hermann C Reichenspurner and Robert Clayton Robbins and Rudolf Jaenisch and Irving L Weissman and Sonja Schrepfer},
  journal={Cell stem cell},
  year={2015},
  volume={16 1},
  pages={33-8}
}
The generation of pluripotent stem cells by somatic cell nuclear transfer (SCNT) has recently been achieved in human cells and sparked new interest in this technology. The authors reporting this methodical breakthrough speculated that SCNT would allow the creation of patient-matched embryonic stem cells, even in patients with hereditary mitochondrial diseases. However, herein we show that mismatched mitochondria in nuclear-transfer-derived embryonic stem cells (NT-ESCs) possess alloantigenicity… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 39 times. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Heart regeneration.

Biochimica et biophysica acta • 2016
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Similar Papers

Loading similar papers…