SCN3A deficiency associated with increased seizure susceptibility.

Abstract

Mutations in voltage-gated sodium channels expressed highly in the brain (SCN1A, SCN2A, SCN3A, and SCN8A) are responsible for an increasing number of epilepsy syndromes. In particular, mutations in the SCN3A gene, encoding the pore-forming Nav1.3 α subunit, have been identified in patients with focal epilepsy. Biophysical characterization of epilepsy… (More)
DOI: 10.1016/j.nbd.2017.02.006

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@article{Lamar2017SCN3ADA, title={SCN3A deficiency associated with increased seizure susceptibility.}, author={Tyra A Lamar and Carlos G Vanoye and Jeffrey D. Calhoun and Jennifer C. Wong and Stacey B. B. Dutton and Benjamin S Jorge and Milen T Velinov and Andrew Escayg and Jennifer A. Kearney}, journal={Neurobiology of disease}, year={2017}, volume={102}, pages={38-48} }