SCML2 promotes heterochromatin organization in late spermatogenesis.

@article{Maezawa2018SCML2PH,
  title={SCML2 promotes heterochromatin organization in late spermatogenesis.},
  author={So Maezawa and Kazuteru Hasegawa and Kris G. Alavattam and Mayuka Funakoshi and Taiga Sato and Artem Barski and Satoshi H Namekawa},
  journal={Journal of cell science},
  year={2018},
  volume={131 17}
}
Spermatogenesis involves the progressive reorganization of heterochromatin. However, the mechanisms that underlie the dynamic remodeling of heterochromatin remain unknown. Here, we identify SCML2, a germline-specific Polycomb protein, as a critical regulator of heterochromatin organization in spermatogenesis. We show that SCML2 accumulates on pericentromeric heterochromatin (PCH) in male germ cells, where it suppresses PRC1-mediated monoubiquitylation of histone H2A at Lysine 119 (H2AK119ub… CONTINUE READING

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