SCL and associated proteins distinguish active from repressive GATA transcription factor complexes.

@article{Tripic2009SCLAA,
  title={SCL and associated proteins distinguish active from repressive GATA transcription factor complexes.},
  author={Tamara Tripic and Wulan Deng and Yong Cheng and Ying Zhang and Christopher R Vakoc and Gregory D Gregory and Ross C. Hardison and Gerd A Blobel},
  journal={Blood},
  year={2009},
  volume={113 10},
  pages={2191-201}
}
GATA-1 controls hematopoietic development by activating and repressing gene transcription, yet the in vivo mechanisms that specify these opposite activities are unknown. By examining the composition of GATA-1-associated protein complexes in a conditional erythroid rescue system as well as through the use of tiling arrays we detected the SCL/TAL1, LMO2, Ldb1, E2A complex at all positively acting GATA-1-bound elements examined. Similarly, the SCL complex is present at all activating GATA elements… CONTINUE READING

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