SCH 43478 and analogs: in vitro activity and in vivo efficacy of novel agents for herpesvirus type 2.

@article{Albin1997SCH4A,
  title={SCH 43478 and analogs: in vitro activity and in vivo efficacy of novel agents for herpesvirus type 2.},
  author={R. Albin and R. Chase and C. Risano and M. Lieberman and E. Ferrari and A. Skelton and P. Buontempo and S. Cox and J. DeMartino and J. Wright-Minogue and G. Jirau-Lucca and J. Kelly and A. Afonso and A. Kwong and E. Rozhon and J. O'Connell},
  journal={Antiviral research},
  year={1997},
  volume={35 3},
  pages={
          139-46
        }
}
  • R. Albin, R. Chase, +13 authors J. O'Connell
  • Published 1997
  • Biology, Medicine
  • Antiviral research
  • SCH 43478 and analogs are a class of non-nucleoside antiviral agents that have potent and selective activity against herpes simplex virus type 2 (HSV-2). The IC50 for these compounds in plaque reduction analysis using Vero cells ranges from 0.8 to 2.0 microg/ml. All compounds have a LC50 > 100 microg/ml in cytotoxicity analysis. Mechanism of action studies suggest that these molecules have an effect on the transactivation of viral immediate early (alpha) gene expression. Time of addition… CONTINUE READING
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