SCH 39166, a potential antipsychotic drug, does not evoke movement disorders in cebus monkeys

@article{Coffin1992SCH3A,
  title={SCH 39166, a potential antipsychotic drug, does not evoke movement disorders in cebus monkeys},
  author={Vicki Lynn Coffin and Daniel McHuch and Richard E. Chipkin and Allen M. Barnett},
  journal={Neurochemistry International},
  year={1992},
  volume={20},
  pages={141-145}
}
Subchronic administration of a neuroleptic in cebus monkeys can reliably mimic the abnormal movements produced by these drugs in humans. SCH 39166 is the best candidate to test in this model to determine if selective antagonism at the dopamine D1 receptor is devoid of these side effects. It has superior selectivity for the dopamine D1 site versus several other sites and a significantly longer duration in primates than the prototypical D1 antagonist, SCH 23390. In contrast to haloperidol, weekly… CONTINUE READING
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