SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells.

@article{Ng2009SCG10likeP,
  title={SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells.},
  author={Dominic C. H. Ng and Cheh Peng Lim and Bao Hong Lin and Tong Zhang and Xinmin Cao},
  journal={The Biochemical journal},
  year={2009},
  volume={425 1},
  pages={95-105}
}
STAT (signal transducer and activator of transcription) 3 is a key contributor to cancer cell migration and invasion, with excessive STAT3 activity promoting growth arrest, cell-cell dissociation and increased migration of breast cancer epithelial cells. The STAT3-regulated mechanisms involved in this process, however, are not fully defined. Previously, we had revealed SCLIP [SCG10 (superior cervical ganglia protein 10)-like protein] as a novel STAT3-interacting protein. In the present study… CONTINUE READING