SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor.

@article{Kumar2003SCFHOSUL,
  title={SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor.},
  author={K. G. Suresh Kumar and Weigang Tang and Abhilash K. Ravindranath and William A. Clark and E. M. Croze and Serge Yu. Fuchs},
  journal={The EMBO journal},
  year={2003},
  volume={22 20},
  pages={5480-90}
}
Down-regulation of activated signaling receptors in response to their ligands plays a key role in restricting the extent and duration of the signaling. Mechanisms underlying down-regulation of the type I interferon receptor consisting of IFNAR1 and IFNAR2 subunits remain largely unknown. Here we show that IFNAR1 interacts with the Homolog of Slimb (HOS) F-box protein in a phosphorylation-dependent manner, and that this interaction is promoted by interferon alpha (IFNalpha). IFNAR1 is… CONTINUE READING
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