SCD5-induced oleic acid production reduces melanoma malignancy by intracellular retention of SPARC and cathepsin B.

@article{Bellenghi2015SCD5inducedOA,
  title={SCD5-induced oleic acid production reduces melanoma malignancy by intracellular retention of SPARC and cathepsin B.},
  author={Maria Bellenghi and Rossella Puglisi and Francesca Pedini and Alessandra De Feo and Federica Felicetti and Lisabianca Bottero and Sabina Sangaletti and Maria Cristina Errico and Marina Ferreyra Petrini and Cinzia Gesumundo and Massimo Denaro and Nadia Felli and Luca Pasquini and Claudio Tripodo and Mario P Colombo and Alessandra Car{\`e} and Gianfranco Mattia},
  journal={The Journal of pathology},
  year={2015},
  volume={236 3},
  pages={
          315-25
        }
}
A proper balance between saturated and unsaturated fatty acids (FAs) is required for maintaining cell homeostasis. The increased demand of FAs to assemble the plasma membranes of continuously dividing cancer cells might unbalance this ratio and critically affect tumour outgrowth. We unveiled the role of the stearoyl-CoA desaturase SCD5 in converting saturated FAs into mono-unsaturated FAs during melanoma progression. SCD5 is down-regulated in advanced melanoma and its restored expression… CONTINUE READING
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