SCD1 Inhibition Causes Cancer Cell Death by Depleting Mono-Unsaturated Fatty Acids

@inproceedings{Mason2012SCD1IC,
  title={SCD1 Inhibition Causes Cancer Cell Death by Depleting Mono-Unsaturated Fatty Acids},
  author={Paul M. Mason and Beirong Liang and Lingyun Li and Trisha Fremgen and Erin E. Murphy and Angela Hesener Quinn and Stephen L. Madden and Hans-Peter N Biemann and Bing Wang and Aharon Cohen and Svetlana Komarnitsky and Kate Jancsics and Brad Hirth and Christopher G. F. Cooper and Edward Lee and Sean Wilson and Roy D. Krumbholz and Steven M. Schmid and Yibin Xiang and M. Booker and James Lillie and Kara Carter},
  booktitle={PloS one},
  year={2012}
}
Increased metabolism is a requirement for tumor cell proliferation. To understand the dependence of tumor cells on fatty acid metabolism, we evaluated various nodes of the fatty acid synthesis pathway. Using RNAi we have demonstrated that depletion of fatty-acid synthesis pathway enzymes SCD1, FASN, or ACC1 in HCT116 colon cancer cells results in cytotoxicity that is reversible by addition of exogenous fatty acids. This conditional phenotype is most pronounced when SCD1 is depleted. We used… CONTINUE READING