SCA 1, SCA 2 & SCA 3/MJD mutations in ataxia syndromes in southern India.

@article{Krishna2007SCA1S,
  title={SCA 1, SCA 2 & SCA 3/MJD mutations in ataxia syndromes in southern India.},
  author={N. Muddula Krishna and Surendra Mohan and B. S. Yashavantha and A Rammurthy and H B Kiran Kumar and Uma Mittal and Shivani Tyagi and Mitali Mukerji and Sanjeev R. Jain and Pramod Kumar Pal and Meera Purushottam},
  journal={The Indian journal of medical research},
  year={2007},
  volume={126 5},
  pages={465-70}
}
BACKGROUND & OBJECTIVE Spinocerebellar ataxias (SCAs) are often caused by expansions of CTG/ CAG trinucleotide repeat in the genome. Expansions at the SCA1, 2 and 3 loci are the most frequent, but differences in their relative proportion in regions occur across the world. We carried out this study to assess the occurrence of SCA1, 2 and 3, at a tertiary neuro-psychiatric center in Bangalore, Karnataka. METHODS Probands (N=318) who were diagnosed to have an ataxia syndrome (progressive… CONTINUE READING