SBMLSimulator: A Java Tool for Model Simulation and Parameter Estimation in Systems Biology

@article{Drr2014SBMLSimulatorAJ,
  title={SBMLSimulator: A Java Tool for Model Simulation and Parameter Estimation in Systems Biology},
  author={Alexander D{\"o}rr and Roland Keller and Andreas Zell and Andreas Dr{\"a}ger},
  journal={Computation},
  year={2014},
  volume={2},
  pages={246-257}
}
The identification of suitable model parameters for biochemical reactions has been recognized as a quite difficult endeavor. Parameter values from literature or experiments can often not directly be combined in complex reaction systems. Nature-inspired optimization techniques can find appropriate sets of parameters that calibrate a model to experimentally obtained time series data. We present SBMLsimulator, a tool that combines the Systems Biology Simulation Core Library for dynamic simulation… CONTINUE READING
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