SB203580 Modulates p38 MAPK Signaling and Dengue Virus-Induced Liver Injury by Reducing MAPKAPK2, HSP27, and ATF2 Phosphorylation

@inproceedings{Sreekanth2016SB203580MP,
  title={SB203580 Modulates p38 MAPK Signaling and Dengue Virus-Induced Liver Injury by Reducing MAPKAPK2, HSP27, and ATF2 Phosphorylation},
  author={Gopinathan Pillai Sreekanth and Aporn Chuncharunee and Aunchalee Sirimontaporn and Jutatip Panaampon and Sansanee Noisakran and Pa-Thai Yenchitsomanus and Thawornchai Limjindaporn and Yi-Hsien Hsieh},
  booktitle={PloS one},
  year={2016}
}
Dengue virus (DENV) infection causes organ injuries, and the liver is one of the most important sites of DENV infection, where viral replication generates a high viral load. The molecular mechanism of DENV-induced liver injury is still under investigation. The mitogen activated protein kinases (MAPKs), including p38 MAPK, have roles in the hepatic cell apoptosis induced by DENV. However, the in vivo role of p38 MAPK in DENV-induced liver injury is not fully understood. In this study, we… CONTINUE READING