SB-699551-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: Evidence for an autoreceptor role for the 5-ht5A receptor in guinea pig brain.

@article{Thomas2006SB699551AD,
  title={SB-699551-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-\{[(2-phenylethyl)amino]methyl\}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: Evidence for an autoreceptor role for the 5-ht5A receptor in guinea pig brain.},
  author={David Richard Thomas and Ellen M Soffin and Claire Roberts and James N. C. Kew and Raul M de la Flor and Lee A. Dawson and Victoria Anne Honey Fry and Sara A Coggon and Stefania Faedo and Philip D Hayes and David F Corbett and Ceri Hywel Davies and Jim J. Hagan},
  journal={Neuropharmacology},
  year={2006},
  volume={51 3},
  pages={566-77}
}
This study utilised the selective 5-ht(5A) receptor antagonist, SB-699551-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), to investigate 5-ht5A receptor function in guinea pig brain. SB-699551-A competitively antagonised 5-HT-stimulated [35S]GTPgammaS binding to membranes from human embryonic kidney (HEK293) cells transiently expressing the guinea pig 5-ht5A receptor (pA2 8.1+/-0.1) and displayed 100-fold… CONTINUE READING
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