SB-649915-B, a Novel 5-HT1A/B Autoreceptor Antagonist and Serotonin Reuptake Inhibitor, is Anxiolytic and Displays Fast Onset Activity in the Rat High Light Social Interaction Test

@article{Starr2007SB649915BAN,
  title={SB-649915-B, a Novel 5-HT1A/B Autoreceptor Antagonist and Serotonin Reuptake Inhibitor, is Anxiolytic and Displays Fast Onset Activity in the Rat High Light Social Interaction Test},
  author={Kathryn R. Starr and Gary W Price and Jeannette M. Watson and Peter J. Atkinson and Roberto Arban and Sergio Melotto and Lee A. Dawson and Jim J. Hagan and Neil Upton and Mark S. Duxon},
  journal={Neuropsychopharmacology},
  year={2007},
  volume={32},
  pages={2163-2172}
}
Preclinically, the combination of an SSRI and 5-HT autoreceptor antagonist has been shown to reduce the time to onset of anxiolytic activity compared to an SSRI alone. In accordance with this, clinical data suggest the coadministration of an SSRI and (±) pindolol can decrease the time to onset of anxiolytic/antidepressant activity. Thus, the dual-acting novel SSRI and 5-HT1A/B receptor antagonist, SB-649915-B, has been assessed in acute and chronic preclinical models of anxiolysis. SB-649915-B… CONTINUE READING
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