SB-219383, a novel tyrosyl tRNA synthetase inhibitor from a Micromonospora sp. I. Fermentation, isolation and properties.

@article{Stefanska2000SB219383AN,
  title={SB-219383, a novel tyrosyl tRNA synthetase inhibitor from a Micromonospora sp. I. Fermentation, isolation and properties.},
  author={Anna L. Stefanska and Nigel J Coates and L M Mensah and Andrew J. Pope and Sarah J. Ready and Stephen R. Warr},
  journal={The Journal of antibiotics},
  year={2000},
  volume={53 4},
  pages={345-50}
}
A novel, potent and selective inhibitor of bacterial tyrosyl tRNA synthetase, designated SB-219383 has been isolated from Micromonospora sp. NCIMB 40684. The fermentation, isolation and some properties are described, whilst the structure determination is described in the succeeding paper). SB-219383 showed competitive, inhibitory activity against a Staphylococcus tyrosyl tRNA synthetase, with an IC50 of <1 nM, and exhibited weak in vitro activity against some Streptococcus sp. 

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References

Publications referenced by this paper.
Showing 1-10 of 13 references

Bell : SB - 219383 , a novel tyrosyl tRNA synthetase inhibitor from a Micromonosporasp . II . Structure determination

C Houge-Frydrych
J . Antibiotics • 2000

Aminoacyl tRNA synthetases as targets for new anti-infectives.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 1998

Gafit Version 3.0

R. J. 1998 Leatherbarrow
Erithacus Software Ltd., • 1992

The Chemotaxonomy of Actinomycetes

Williams, Wilkins
1989

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