SATB1 promotes prostate cancer metastasis by the regulation of epithelial-mesenchymal transition.

@article{Mao2016SATB1PP,
  title={SATB1 promotes prostate cancer metastasis by the regulation of epithelial-mesenchymal transition.},
  author={Li-jun Mao and Chun-hua Yang and Li Fan and Peng Gao and Dong-rong Yang and Bo-xin Xue and Junnian Zheng and Yu-xi Shan},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2016},
  volume={79},
  pages={
          1-8
        }
}
Special AT-rich sequence binding protein 1 (SATB1) plays important role in the regulation of chromatin structure and gene expression. Recent studies have indicated oncogenic role of SATB1. However, the function of SATB1 in prostate cancer progression and metastasis remains unclear. In this study SATB1 expression vector or siRNA was employed to modulate the expression level of SATB1 in prostate cancer cells and xenograft tumor in nude mouse model. Immunohistochemical analysis was performed on… CONTINUE READING

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