SATB1 Makes a Complex with p300 and Represses gp91phox Promoter Activity

@article{Fujii2003SATB1MA,
  title={SATB1 Makes a Complex with p300 and Represses gp91phox Promoter Activity},
  author={Yoshito Fujii and Atsushi Kumatori and Michio Nakamura},
  journal={Microbiology and Immunology},
  year={2003},
  volume={47}
}
The expression of gp91phox, the key component of the phagocyte NADPH oxidase, is regulated by various factors binding to its proximal promoter. Two nuclear matrix attachment region (MAR)‐binding proteins, special AT‐rich binding protein 1 (SATB1) and CCAAT displacement protein (CDP), have been reported as rare examples of gp91phox gene repressors. However, their individual roles and interactions with other factors in the promoter have not been elucidated in detail. We have focused on these two… 
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22 Citations
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22 Citations

A novel SATB1 binding site in the BCL2 promoter region possesses transcriptional regulatory function☆
Tetramerization of SATB1 is essential for regulating of gene expression
TLDR
Whether SATB1’s oligomerization is critical to its function as a global repressor of gene expression in vivo is illustrated to illustrate.
SMAR1 and Cux/CDP modulate chromatin and act as negative regulators of the TCRβ enhancer (Eβ)
TLDR
It is shown here that overexpression of the MAR binding proteins SMAR1 and Cux/CDP modulate the chromatin structure at MARβ, suggesting that at the double positive stage of T cell development, cis-acting MARβ elements recruit the strong negative regulators Cux andSMAR1 to control Eβ-mediated recombination and transcription.
The BCL2 gene is regulated by a special AT-rich sequence binding protein 1-mediated long range chromosomal interaction between the promoter and the distal element located within the 3′-UTR
TLDR
A novel mechanism of BCL2 regulation is revealed and SATB1-mediated long-range interaction with the regulation of a gene controlling apoptosis pathway is mechanistically link for the first time.
Chromatin‐bound bacterial effector ankyrin A recruits histone deacetylase 1 and modifies host gene expression
TLDR
This novel microbial manipulation of host chromatin and gene expression provides important evidence of the direct effects that prokaryotic nuclear effectors can exert over host transcription and function.
SATB1-mediated chromatin landscape in T cells
TLDR
SATB1 is a multivalent tissue-specific factor with a broad and yet undetermined regulatory potential and the most apparent mechanism of its involvement in gene expression regulation is via the orchestration of long-range chromatin loops between genes and their regulatory elements.
Unraveling the role of H3K4 trimethylation and lncRNA HOTAIR in SATB1 and DUSP4-dependent survival of virulent Mycobacterium tuberculosis in macrophages.
SATB1 family protein expressed during early erythroid differentiation modifies globin gene expression.
TLDR
The results suggest that SATB1 can up-regulate the epsilon- globin gene by interaction with specific sites in the beta-globin cluster and imply that SATb1 family protein expressed in the erythroid progenitor cells may have a role in globin gene expression during early erythyroid differentiation.
SATB1 binds an intronic MAR sequence in human PI3kγ in vitro
TLDR
Results indicate that SATB1 may play antagonistic roles in PI3Kγ transcriptional regulation and Southwestern blot analysis indicates that recombinant SATB 1 directly binds PIMAR sequence in vitro.
Lessons from Anaplasma phagocytophilum: Chromatin Remodeling by Bacterial Effectors
TLDR
This review will focus on how bacterial pathogens alter host epigenetics, by specifically examining A. phagocytophilum AnkA cis-regulation of CYBB transcription and epigenetic changes associated with infection.
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References

SHOWING 1-10 OF 24 REFERENCES
Homeoproteins CDP and SATB1 Interact: Potential for Tissue-Specific Regulation
TLDR
It is proposed that the SATB1-to-CDP ratio in different tissues is a novel mechanism for homeoproteins to control gene expression and differentiation in mammals.
Overexpression of CCAAT Displacement Protein Represses the Promiscuously Active Proximal gp91phox Promoter
TLDR
The complex interplay between transcriptional activators and a repressor that contribute to the myeloid-restricted expression of the gp91 phox gene is illustrated.
CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter.
The matrix attachment region-binding protein SATB1 participates in negative regulation of tissue-specific gene expression
TLDR
It is shown here that NBP binds to a 22-bp sequence containing an imperfect inverted repeat in the promoter-proximal NRE, which demonstrates the role of MAR-binding proteins in tissue-specific gene regulation and in MMTV-induced oncogenesis.
The Matrix Attachment Region-binding Protein SATB1 Interacts with Multiple Elements within the gp91 phox Promoter and Is Down-regulated during Myeloid Differentiation*
TLDR
Findings underscore the importance of transcriptional repression in the regulation of gp91 phox expression and reveal a candidate myeloid cell target gene for SATB1, a factor previously found to be essential for T cell development.
CREB-binding Protein and p300 in Transcriptional Regulation*
TLDR
Whether CBP and p300 have distinct functions is asked, the evidence for their regulation by phosphorylation is reviewed, and whether they function primarily by acetylating histones or other proteins are revisited.
Modulated Binding of SATB1, a Matrix Attachment Region Protein, to the AT-Rich Sequence Flanking the Major Breakpoint Region of BCL2
TLDR
In vivo binding of SATB1 to the MBR is demonstrated, strongly suggesting the BCL2 major breakpoint region is a MAR, and the potential consequences of these observations for both MBR fragility and regulatory function are discussed.
CCAAT Displacement Protein Competes with Multiple Transcriptional Activators for Binding to Four Sites in the Proximal gp91phox Promoter*
TLDR
A model in which restriction of gp91phox expression to mature myeloid cells involves competition between transcriptional activators and repressors for binding to multiple sites within the promoter is presented.
PU.1 is dominant and HAF-1 supplementary for activation of the gp91(phox) promoter in human monocytic PLB-985 cells.
TLDR
It is concluded that PU.1 and HAF-1 binding to the Pu box is dominant and supplementary, respectively, for activation of the gp91(phox) promoter in human monocytic cells.
Eosinophil-specific Regulation of gp91 phox Gene Expression by Transcription Factors GATA-1 and GATA-2*
TLDR
GATA-1 is an activator and that GATA-2 is a relative competitive inhibitor of Gata-1 in the expression of the gp91 phox gene in human eosinophils are suggested.
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