SATB1 Makes a Complex with p300 and Represses gp91phox Promoter Activity

@article{Fujii2003SATB1MA,
  title={SATB1 Makes a Complex with p300 and Represses gp91phox Promoter Activity},
  author={Yoshito Fujii and Atsushi Kumatori and Michio Nakamura},
  journal={Microbiology and Immunology},
  year={2003},
  volume={47}
}
The expression of gp91phox, the key component of the phagocyte NADPH oxidase, is regulated by various factors binding to its proximal promoter. Two nuclear matrix attachment region (MAR)‐binding proteins, special AT‐rich binding protein 1 (SATB1) and CCAAT displacement protein (CDP), have been reported as rare examples of gp91phox gene repressors. However, their individual roles and interactions with other factors in the promoter have not been elucidated in detail. We have focused on these two… 
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TLDR
It is proposed that the SATB1-to-CDP ratio in different tissues is a novel mechanism for homeoproteins to control gene expression and differentiation in mammals.
Overexpression of CCAAT Displacement Protein Represses the Promiscuously Active Proximal gp91phox Promoter
TLDR
The complex interplay between transcriptional activators and a repressor that contribute to the myeloid-restricted expression of the gp91 phox gene is illustrated.
The matrix attachment region-binding protein SATB1 participates in negative regulation of tissue-specific gene expression
TLDR
It is shown here that NBP binds to a 22-bp sequence containing an imperfect inverted repeat in the promoter-proximal NRE, which demonstrates the role of MAR-binding proteins in tissue-specific gene regulation and in MMTV-induced oncogenesis.
The Matrix Attachment Region-binding Protein SATB1 Interacts with Multiple Elements within the gp91 phox Promoter and Is Down-regulated during Myeloid Differentiation*
TLDR
Findings underscore the importance of transcriptional repression in the regulation of gp91 phox expression and reveal a candidate myeloid cell target gene for SATB1, a factor previously found to be essential for T cell development.
CREB-binding Protein and p300 in Transcriptional Regulation*
TLDR
Whether CBP and p300 have distinct functions is asked, the evidence for their regulation by phosphorylation is reviewed, and whether they function primarily by acetylating histones or other proteins are revisited.
Modulated Binding of SATB1, a Matrix Attachment Region Protein, to the AT-Rich Sequence Flanking the Major Breakpoint Region of BCL2
TLDR
In vivo binding of SATB1 to the MBR is demonstrated, strongly suggesting the BCL2 major breakpoint region is a MAR, and the potential consequences of these observations for both MBR fragility and regulatory function are discussed.
CCAAT Displacement Protein Competes with Multiple Transcriptional Activators for Binding to Four Sites in the Proximal gp91phox Promoter*
TLDR
A model in which restriction of gp91phox expression to mature myeloid cells involves competition between transcriptional activators and repressors for binding to multiple sites within the promoter is presented.
PU.1 is dominant and HAF-1 supplementary for activation of the gp91(phox) promoter in human monocytic PLB-985 cells.
TLDR
It is concluded that PU.1 and HAF-1 binding to the Pu box is dominant and supplementary, respectively, for activation of the gp91(phox) promoter in human monocytic cells.
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TLDR
GATA-1 is an activator and that GATA-2 is a relative competitive inhibitor of Gata-1 in the expression of the gp91 phox gene in human eosinophils are suggested.
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