SASH1 is a scaffold molecule in endothelial TLR4 signaling.


Recognition of microbial products by TLRs is critical for mediating innate immune responses to invading pathogens. In this study, we identify a novel scaffold protein in TLR4 signaling called SAM and SH3 domain containing protein 1 (SASH1). Sash1 is expressed across all microvascular beds and functions as a scaffold molecule to independently bind TRAF6… (More)
DOI: 10.4049/jimmunol.1200583


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@article{Dauphinee2013SASH1IA, title={SASH1 is a scaffold molecule in endothelial TLR4 signaling.}, author={Shauna M. Dauphinee and Ashley Clayton and Angela Hussainkhel and Cindy Lai Hung Yang and Yoo-Jin Park and Megan E. Fuller and Josip Blonder and Timothy D. Veenstra and Aly Karsan}, journal={Journal of immunology}, year={2013}, volume={191 2}, pages={892-901} }