SAS-6 is a Cartwheel Protein that Establishes the 9-Fold Symmetry of the Centriole

@article{Nakazawa2007SAS6IA,
  title={SAS-6 is a Cartwheel Protein that Establishes the 9-Fold Symmetry of the Centriole},
  author={Yuki Nakazawa and Madoka Hiraki and Ritsu Kamiya and Masafumi Hirono},
  journal={Current Biology},
  year={2007},
  volume={17},
  pages={2169-2174}
}
Centrioles consist of nine-triplet microtubules arranged in rotational symmetry. This structure is highly conserved among various eukaryotic organisms and serves as the base for the ciliary axoneme. Recently, several proteins such as SAS-6 have been identified as essential to the early process of centriole assembly, but the mechanism that produces the 9-fold symmetry is poorly understood. In C. elegans and Drosophila, SAS-6 has been suggested to function in the formation of a centriolar… CONTINUE READING
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