SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells

@article{Leidel2005SAS6DA,
  title={SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells},
  author={Sebastian Leidel and Marie Delattre and Lorenzo Cerutti and Karine Baumer and Pierre G{\"o}nczy},
  journal={Nature Cell Biology},
  year={2005},
  volume={7},
  pages={115-125}
}
The mechanisms that ensure centrosome duplication are poorly understood. In Caenorhabditis elegans, ZYG-1, SAS-4, SAS-5 and SPD-2 are required for centriole formation. However, it is unclear whether these proteins have functional homologues in other organisms. Here, we identify SAS-6 as a component that is required for daughter centriole formation in C. elegans. SAS-6 is a coiled-coil protein that is recruited to centrioles at the onset of the centrosome duplication cycle. Our analysis… CONTINUE READING

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