SARS-Coronavirus Open Reading Frame-9b Suppresses Innate Immunity by Targeting Mitochondria and the MAVS/TRAF3/TRAF6 Signalosome

@article{Shi2014SARSCoronavirusOR,
  title={SARS-Coronavirus Open Reading Frame-9b Suppresses Innate Immunity by Targeting Mitochondria and the MAVS/TRAF3/TRAF6 Signalosome},
  author={C. Shi and H. Qi and C. Boularan and N. Huang and M. Abu-Asab and J. Shelhamer and J. Kehrl},
  journal={The Journal of Immunology},
  year={2014},
  volume={193},
  pages={3080 - 3089}
}
Coronaviruses (CoV) have recently emerged as potentially serious pathogens that can cause significant human morbidity and death. The severe acute respiratory syndrome (SARS)-CoV was identified as the etiologic agent of the 2002–2003 international SARS outbreak. Yet, how SARS evades innate immune responses to cause human disease remains poorly understood. In this study, we show that a protein encoded by SARS-CoV designated as open reading frame-9b (ORF-9b) localizes to mitochondria and causes… Expand

Paper Mentions

Observational Clinical Trial
COVID-19 patients with a severely symptomatic progression with development of an Acute respiratory distress syndrome (ARDS) due to SARS-CoV-2 need prolonged intensive care… Expand
ConditionsCorona Virus Infection, COVID, Sars-CoV2
InterventionProcedure
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