SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls.

@article{Bert2020SARSCoV2specificTC,
  title={SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls.},
  author={Nina Le Bert and A. T. Tan and Kamini Kunasegaran and Christine Y.L. Tham and Morteza Hafezi and Adeline Chia and Melissa Hui Yen Chng and Meiyin Lin and Nicole Wei Wen Tan and Martin Linster and Wan Ni Chia and Mark I-C Chen and Lin-Fa Wang and Eng Eong Ooi and Shirin Kalimuddin and Paul Anantharajal Tambyah and Jenny Guek-Hong Low and Yee-Joo Tan and Antonio Bertoletti},
  journal={Nature},
  year={2020}
}
  • Nina Le Bert, A. T. Tan, +16 authors Antonio Bertoletti
  • Published 2020
  • Medicine
  • Nature
  • Memory T cells induced by previous pathogens can shape the susceptibility to, and clinical severity of, subsequent infections1. Little is known about the presence of pre-existing memory T cells in humans with the potential to recognize SARS-CoV-2. Here, we first studied T cell responses to structural (nucleocapsid protein, NP) and non-structural (NSP-7 and NSP13 of ORF1) regions of SARS-CoV-2 in COVID-19 convalescents (n=36). In all of them we demonstrated the presence of CD4 and CD8 T cells… CONTINUE READING