SARS-CoV-2 invades host cells via a novel route: CD147-spike protein

@article{Wang2020SARSCoV2IH,
  title={SARS-CoV-2 invades host cells via a novel route: CD147-spike protein},
  author={Kening Wang and Wenjie Chen and Yusen Zhou and Jianqi Lian and Zheng Zhang and Peiwei Du and Li Gong and Yang Zhang and Hong-yong Cui and Jie-jie Geng and B Wang and Xiu-Xuan Sun and Chunfu Wang and Xu Yang and Peng Lin and Yong-Qiang Deng and Ding Wei and Xiang-min Yang and Yumeng Zhu and Kui Zhang and Zhao-hui Zheng and Jin-lin Miao and Ting Guo and Ying Shi and Jun Zhang and Ling Fu and Qingyi Wang and Huijie Bian and Pengfei Zhu and Zhi-nan Chen},
  journal={bioRxiv},
  year={2020}
}
  • Kening Wang, Wenjie Chen, +27 authors Zhi-nan Chen
  • Published 2020
  • Biology
  • bioRxiv
  • Currently, COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been widely spread around the world; nevertheless, so far there exist no specific antiviral drugs for treatment of the disease, which poses great challenge to control and contain the virus. Here, we reported a research finding that SARS-CoV-2 invaded host cells via a novel route of CD147-spike protein (SP). SP bound to CD147, a receptor on the host cells, thereby mediating the viral invasion. Our… CONTINUE READING

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