SARS-CoV-2 invades host cells via a novel route: CD147-spike protein

@article{Wang2020SARSCoV2IH,
  title={SARS-CoV-2 invades host cells via a novel route: CD147-spike protein},
  author={K. Wang and W. Chen and Y. Zhou and J. Lian and Z. Zhang and Peng Du and L. Gong and Yang Zhang and Hong-yong Cui and Jie-jie Geng and B. Wang and X. Sun and Chun-fu Wang and X. Yang and P. Lin and Yong-Qiang Deng and D. Wei and Yumeng Zhu and K. Zhang and Z. Zheng and J. Miao and Ting Guo and Y. Shi and Jun Zhang and Ling Fu and Qingyi Wang and H. Bian and P. Zhu and Zhi-nan Chen},
  journal={bioRxiv},
  year={2020}
}
Currently, COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been widely spread around the world; nevertheless, so far there exist no specific antiviral drugs for treatment of the disease, which poses great challenge to control and contain the virus. Here, we reported a research finding that SARS-CoV-2 invaded host cells via a novel route of CD147-spike protein (SP). SP bound to CD147, a receptor on the host cells, thereby mediating the viral invasion. Our… Expand
356 Citations
Landscape of SARS-CoV-2 spike protein-interacting cells in human tissues
  • 1
SARS–CoV-2 Immuno-Pathogenesis and Potential for Diverse Vaccines and Therapies: Opportunities and Challenges
  • PDF
SARS-CoV-2 proteins and anti-COVID-19 drugs induce lytic reactivation of an oncogenic virus
  • 1
  • PDF
Novel insights into the treatment of SARS-CoV-2 infection: An overview of current clinical trials
  • 7
  • PDF
The Potential Intermediate Hosts for SARS-CoV-2
  • 17
SARS-CoV-2 and Human Immunodeficiency Virus: Pathogen Pincer Attack
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 30 REFERENCES
Coronavirus envelope protein: current knowledge
  • 725
Coronavirus Spike Protein and Tropism Changes
  • 184
Function of HAb18G/CD147 in Invasion of Host Cells by Severe Acute Respiratory Syndrome Coronavirus
  • 145
  • PDF
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
  • 3,422
  • PDF
A novel coronavirus (2019-nCoV) causing pneumonia-associated respiratory syndrome
  • 75
  • PDF
CD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A
  • 198
  • PDF
Mechanisms and enzymes involved in SARS coronavirus genome expression.
  • 638
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
  • 3,398
  • PDF
Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome
  • 2,126
  • PDF
...
1
2
3
...