SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

@article{Sungnak2020SARSCoV2EF,
  title={SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes},
  author={Waradon Sungnak and Ni Huang and Christophe B{\'e}cavin and Marijn Berg and Rachel Queen and Monika Litviňukov{\'a} and Carlos Talavera-L{\'o}pez and Henrike Maatz and Daniel Reichart and Fotios Sampaziotis and Kaylee B. Worlock and Masahiro Yoshida and Josephine L. Barnes and Nicholas E. Pascal Alvis Joseph Tushar J. Thu Elizabeth Oli Banovich Barbry Brazma Collin Desai Duong Eickelbe and Nicholas E. Banovich and Pascal Barbry and Alvis Brazma and Joseph Collin and Tushar J. Desai and Thu Elizabeth Duong and Oliver Eickelberg and Christine S. Falk and M. Farzan and Ian A. Glass and Ravindra K. Gupta and Muzlifah A. Haniffa and P{\'e}ter Horv{\'a}th and Norbert Hubner and Deborah T. Hung and Naftali Kaminski and Mark A. Krasnow and Jonathan A. Kropski and Malte Kuhnemund and Majlinda Lako and Haeock Lee and Sylvie Leroy and Sten Linnarson and Joakim Lundeberg and Kerstin B. Meyer and Zhichao Miao and Alexander V. Misharin and Martijn C. Nawijn and Marko Z. Nikoli{\'c} and Michela Noseda and Jose Ordovas-Montanes and Gavin Y. Oudit and Dana Pe’er and Joseph E. Powell and Steve Quake and Jayaraj Rajagopal and Purushothama Rao Tata and Emma L. Rawlins and Aviv Regev and Paul A. Reyfman and Orit Rozenblatt-Rosen and Kourosh Saeb‐Parsy and Christos Samakovlis and Herbert B. Schiller and Joachim L. Schultze and Max A. Seibold and Christine E. Seidman and Jonathan G. Seidman and Alex K. Shalek and Douglas P. Shepherd and Jason S. Spence and Avi Spira and Xin Sun and Sarah A. Teichmann and Fabian J Theis and Alexander M. Tsankov and Ludovic Vallier and Maarten van den Berge and Jeffrey A. Whitsett and Ramnik J. Xavier and Yan Xu and Laure-Emmanuelle Zaragosi and Darin Zerti and Hongbo Zhang and Kun Zhang and Mauricio M. Rojas and Francisco Figueiredo},
  journal={Nature Medicine},
  year={2020},
  volume={26},
  pages={681-687}
}
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial… 
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References

SHOWING 1-10 OF 91 REFERENCES
A pneumonia outbreak associated with a new coronavirus of probable bat origin
TLDR
Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
A cellular census of human lungs identifies novel cell states in health and in asthma
TLDR
Single-cell transcriptomics reveals immune and stromal compartment remodeling, including the enrichment of unique populations of epithelial cells and CD4+ T cells, in asthmatic lungs.
Angiotensin-converting enzyme 2 in lung diseases
Clinical characteristics of hospitalized patients with SARS‐CoV‐2 infection: A single arm meta‐analysis
TLDR
Analyzing all the published studies on the clinical characteristics of patients with SARS‐CoV‐2 finds reliable evidence of evidence‐based medicine for the treatment and prevention of the Severe Acute Respiratory Syndrome Coronavirus 2.
Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding
TLDR
Children infected with the COVID-19 outbreak coronavirus, SARS-CoV-2, show mild symptoms but prolonged shedding of viral RNA in feces, suggesting that the fecal–oral route might play a role in virus transmission.
Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection
TLDR
This study constructed a risk map indicating the vulnerability of different organs to 2019-nCoV infection, and identified the organs at risk, such as lung, heart, esophagus, kidney, bladder, and ileum, and located specific cell types (i.e., type II alveolar cells (AT2), myocardial cells, proximal tubule cells of the kidney, ileal cells, and bladder urothelial cells).
Covid-19: UK records first death, as world’s cases exceed 100 000
The first death from covid-19 has been recorded in the UK, while the death toll across the world has exceeded 3300, with China, South Korea, Italy, and Iran having the highest numbers. The UK
Clinical Characteristics of Coronavirus Disease 2019 in China
TLDR
During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.
...
...