SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

  title={SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes},
  author={Waradon Sungnak and Ni Huang and Christophe B{\'e}cavin and Marijn Berg and Rachel Queen and Monika Litviňukov{\'a} and Carlos Talavera-L{\'o}pez and Henrike Maatz and Daniel Reichart and Fotios Sampaziotis and Kaylee B. Worlock and Masahiro Yoshida and Josephine L. Barnes and Nicholas E. Pascal Alvis Joseph Tushar J. Thu Elizabeth Oli Banovich Barbry Brazma Collin Desai Duong Eickelbe and Nicholas E. Banovich and Pascal Barbry and Alvis Brazma and Joseph Collin and Tushar J. Desai and Thu Elizabeth Duong and Oliver Eickelberg and Christine S. Falk and M. Farzan and Ian A. Glass and Ravindra K. Gupta and Muzlifah A. Haniffa and P{\'e}ter Horv{\'a}th and Norbert Hubner and Deborah T. Hung and Naftali Kaminski and Mark A. Krasnow and Jonathan A. Kropski and Malte Kuhnemund and Majlinda Lako and Haeock Lee and Sylvie Leroy and Sten Linnarson and Joakim Lundeberg and Kerstin B. Meyer and Zhichao Miao and Alexander V. Misharin and Martijn C. Nawijn and Marko Z. Nikoli{\'c} and Michela Noseda and Jose Ordovas-Montanes and Gavin Y. Oudit and Dana Pe’er and Joseph E. Powell and Steve Quake and Jayaraj Rajagopal and Purushothama Rao Tata and Emma L. Rawlins and Aviv Regev and Paul A. Reyfman and Orit Rozenblatt-Rosen and Kourosh Saeb‐Parsy and Christos Samakovlis and Herbert B. Schiller and Joachim L. Schultze and Max A. Seibold and Christine E. Seidman and Jonathan G. Seidman and Alex K. Shalek and Douglas P. Shepherd and Jason S. Spence and Avi Spira and Xin Sun and Sarah A. Teichmann and Fabian J Theis and Alexander M. Tsankov and Ludovic Vallier and Maarten van den Berge and Jeffrey A. Whitsett and Ramnik J. Xavier and Yan Xu and Laure-Emmanuelle Zaragosi and Darin Zerti and Hongbo Zhang and Kun Zhang and Mauricio M. Rojas and Francisco Figueiredo},
  journal={Nature Medicine},
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial… 
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