SARS-CoV-2 RBD-Tetanus Toxoid Conjugate Vaccine Induces a Strong Neutralizing Immunity in Preclinical Studies.

  title={SARS-CoV-2 RBD-Tetanus Toxoid Conjugate Vaccine Induces a Strong Neutralizing Immunity in Preclinical Studies.},
  author={Yury Vald{\'e}s-Balb{\'i}n and Darielys Santana-Mederos and Lauren Quintero and Sonsire Fernandez and Laura Rodriguez and Belinda S{\'a}nchez Ram{\'i}rez and Rocmira Perez-Nicado and Claudia Acosta and Yanira M{\'e}ndez and Manuel G Ricardo and Tays Hern{\'a}ndez and Gretchen Bergado and Franciscary Pi and Annet Valdes and Tania Carmenate and Ubel Ram{\'i}rez and Reinaldo Oliva and Jean Pierre Soubal and Raine Garrido and Félix Cardoso and Mario Landys and Humberto Gonz{\'a}lez and Mildrey Fari{\~n}as and Juliet Enriquez and Enrique Noa and Anamary Suarez and Cheng Fang and Luis Ariel Espinosa and Yassel Ramos and Luis Javier Gonz{\'a}lez and Yanet Climent and Gertrudis Rojas and Ernesto Relova-Hern{\'a}ndez and Yanelys Cabrera Infante and Sum Lai Losada and Tammy Boggiano and Eduardo Ojito and Kalet Leon and Fabrizio Chiodo and Françoise Paquet and Guang-Wu Chen and Daniel G. Rivera and Dagmar Garc{\'i}a-Rivera and Vicente Verez Bencomo},
  journal={ACS chemical biology},
Controlling the global COVID-19 pandemic depends, among other measures, on developing preventive vaccines at an unprecedented pace. Vaccines approved for use and those in development intend to elicit neutralizing antibodies to block viral sites binding to the host's cellular receptors. Virus infection is mediated by the spike glycoprotein trimer on the virion surface via its receptor binding domain (RBD). Antibody response to this domain is an important outcome of immunization and correlates… 

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