SARS-COV-2 Variants: Differences and Potential of Immune Evasion

@article{Hirabara2021SARSCOV2VD,
  title={SARS-COV-2 Variants: Differences and Potential of Immune Evasion},
  author={Sandro Massao Hirabara and T D A Serdan and Renata Gorj{\~a}o and Laureane Nunes Masi and Tania Cristina Pithon-Curi and Dimas Tadeu Covas and Rui Curi and Edison L Durigon},
  journal={Frontiers in Cellular and Infection Microbiology},
  year={2021},
  volume={11}
}
The structural spike (S) glycoprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) plays an essential role in infection and is an important target for neutralizing antibody recognition. Mutations in the S gene can generate variants of concern (VOCs), which improve “viral fitness” through selective or survival advantages, such as increased ACE-2 receptor affinity, infectivity, viral replication, higher transmissibility, resistance to neutralizing antibodies and immune escape… 

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