SARS–associated Coronavirus Replication in Cell Lines

@inproceedings{Kaye2006SARSassociatedCR,
  title={SARS–associated Coronavirus Replication in Cell Lines},
  author={Matthew B Kaye and Julian D. Druce and Thomas H. Tran and Renata Kostecki and Doris Chibo and Jessica Ruth Morris and Mike Catton and Chris J. Birch},
  booktitle={Emerging infectious diseases},
  year={2006}
}
Given the potential for laboratory-associated severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infections, we must know which cell lines are susceptible to the virus. We investigated 21 cell lines routinely used for virus isolation or research. After infection with SARS-CoV, cells were observed for cytopathic effects, and quantitative real-time polymerase chain reaction was used to measure ongoing viral replication. An indirect immunofluorescence assay was also used as a… CONTINUE READING

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