SARA is dispensable for functional TGF-β signaling.


Smad anchor for receptor activation (SARA or ZFYVE9) has been proposed to mediate transforming growth factor β (TGF-β) signaling by direct interaction with the non-activated Smad proteins and the TGF-β receptors; however, these findings are controversial. We demonstrate no correlation between SARA expression and the levels of TGF-β-induced phosphorylation of Smads in various B-cell lymphomas. Moreover, knockdown of SARA in HeLa cells did not interfere with TGF-β-induced Smad activation, Smad nuclear translocation, or induction of TGF-β target genes. Various R-Smads and TGF-β receptors did not co-immunoprecipitate with SARA. Collectively, our results demonstrate that SARA is dispensable for functional TGF-β-mediated signaling.

DOI: 10.1016/j.febslet.2012.07.027
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@article{Bakkeb2012SARAID, title={SARA is dispensable for functional TGF-β signaling.}, author={Maren K Bakkeb\o and Kanutte Huse and Vera I. Hilden and Lise Forfang and June Helen Myklebust and Erlend Smeland and Morten P. Oksvold}, journal={FEBS letters}, year={2012}, volume={586 19}, pages={3367-72} }