SARA, a FYVE domain protein, affects Rab5-mediated endocytosis.

  title={SARA, a FYVE domain protein, affects Rab5-mediated endocytosis.},
  author={Yang Hu and J. Z. Chuang and Kai Xu and T. McGraw and C L Sung},
  journal={Journal of cell science},
  volume={115 Pt 24},
Rab5, a member of the small GTPase family of proteins, is primarily localized on early endosomes and has been proposed to participate in the regulation of early endosome trafficking. It has been reported that phosphatidylinositol 3-kinases and FYVE domain proteins, such as EEA1, can be recruited onto early endosomes and act as Rab5 effectors. SARA (Smad anchor for receptor activation), also a FYVE domain protein, was initially isolated as a participant in signal transduction from the… CONTINUE READING

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