SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

  title={SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor},
  author={Tomoo Tsukazaki and Theodore Chiang and Anne F Davison and Liliana Attisano and Jeffrey L. Wrana},
Smads transmit signals from transmembrane ser/thr kinase receptors to the nucleus. We now identify SARA (for Smad anchor for receptor activation), a FYVE domain protein that interacts directly with Smad2 and Smad3. SARA functions to recruit Smad2 to the TGFbeta receptor by controlling the subcellular localization of Smad2 and by interacting with the TGFbeta receptor complex. Phosphorylation of Smad2 induces dissociation from SARA with concomitant formation of Smad2/Smad4 complexes and nuclear… CONTINUE READING
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TGF-b signaling from cell membrane to nucleus through SMAD proteins

  • Heldin, C.-H, K. Miyazono, P. ten Dijke
  • Nature 390,
  • 1997
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