SAR of 3,4-dihydropyrido[3,2-d]pyrimidone p38 inhibitors.


Development for a class of potent 3,4-dihydropyrido(3,2-d)pyrimidone inhibitors of p38a MAP kinase is described. Modification of N-1 aryl and C-6 arylsulfide in 3,4-dihydropyrido(3,2-d)pyrimidone analogues for the interaction with the hydrophobic pockets in p38 active site is also discussed. 


Cite this paper

@article{Liu2003SARO3, title={SAR of 3,4-dihydropyrido[3,2-d]pyrimidone p38 inhibitors.}, author={Luping Liu and John E Stelmach and Swaminathan R. Natarajan and Meng-hsin Chen and Suresh B. Singh and Cheryl D Schwartz and Catherine E Fitzgerald and Stephen J O'keefe and Dennis M. Zaller and Dennis M Schmatz and James B Doherty}, journal={Bioorganic & medicinal chemistry letters}, year={2003}, volume={13 22}, pages={3979-82} }