SAR by ILOEs: an NMR-based approach to reverse chemical genetics.

Abstract

Reverse chemical genetics is an emerging technique that makes use of small molecule inhibitors to characterize how a protein functions. In this regard, we have developed an NMR-based approach (SAR by ILOEs) that enables the identification of high affinity ligands for a given protein target without the need of a specific assay. Our approach is of general… (More)

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Cite this paper

@article{Becattini2006SARBI, title={SAR by ILOEs: an NMR-based approach to reverse chemical genetics.}, author={Barbara Becattini and Maurizio Pellecchia}, journal={Chemistry}, year={2006}, volume={12 10}, pages={2658-62} }