SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist.

@article{Haydar2009SARAB,
  title={SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist.},
  author={Simon N. Haydar and Chiara Ghiron and Laura Bettinetti and Hendrick Bothmann and Thomas A. Comery and John E Dunlop and Salvatore La Rosa and Iolanda Micco and Martina Pollastrini and Joanna R. Quinn and Renza Roncarati and Carla Scali and Michela Valacchi and Maurizio Varrone and Riccardo Zanaletti},
  journal={Bioorganic & medicinal chemistry},
  year={2009},
  volume={17 14},
  pages={
          5247-58
        }
}
Alpha 7 nicotinic acetylcholine receptor (alpha(7) nAChR) agonists are promising therapeutic candidates for the treatment of cognitive impairment associated with a variety of disorders including Alzheimer's disease and schizophrenia. Alpha 7 nAChRs are expressed in brain regions associated with cognitive function, regulate cholinergic neurotransmission and have been shown to be down regulated in both schizophrenia and Alzheimer's disease. Herein we report a novel, potent small molecule agonist… CONTINUE READING
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