SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity.

@article{Burgeson2012SARAO,
  title={SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity.},
  author={James R Burgeson and Amy L Moore and Jordan K. Boutilier and Natasha R Cerruti and Dima N Gharaibeh and Candace E. Lovejoy and Sean M Amberg and Dennis E. Hruby and Shanthakumar R. Tyavanagimatt and Robert D Allen and Dongcheng Dai},
  journal={Bioorganic & medicinal chemistry letters},
  year={2012},
  volume={22 13},
  pages={4263-72}
}
A series of acylthiourea derivatives were designed, synthesized, and evaluated for broad-spectrum antiviral activity with selected viruses from Poxviridae (vaccinia virus) and two different genera of the family Bunyaviridae (Rift Valley fever and La Crosse viruses). A compound selected from a library screen, compound 1, displayed submicromolar antiviral activity against both vaccinia virus (EC(50)=0.25 μM) and La Crosse virus (EC(50)=0.27 μM) in cytopathic effect (CPE) assays. SAR analysis was… CONTINUE READING