SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes.

  title={SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes.},
  author={S{\'e}verine Petitprez and Anne-Flore Zmoos and Jakob Ogrodnik and Elise Balse and Nour Raad and Said El-Haou and Maxime Albesa and Philip Bittihn and Stefan Luther and Stephan E. Lehnart and St{\'e}phane Nicolas Hatem and Alain Coulombe and H. Abriel},
  journal={Circulation research},
  volume={108 3},
RATIONALE The cardiac sodium channel Na(v)1.5 plays a key role in excitability and conduction. The 3 last residues of Na(v)1.5 (Ser-Ile-Val) constitute a PDZ-domain binding motif that interacts with the syntrophin-dystrophin complex. As dystrophin is absent at the intercalated discs, Na(v)1.5 could potentially interact with other, yet unknown, proteins at this site. OBJECTIVE The aim of this study was to determine whether Na(v)1.5 is part of distinct regulatory complexes at lateral membranes… CONTINUE READING

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