SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.


DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV-1 infection, and mutations are associated with Aicardi-Goutières syndrome and cancer. We show that SAMHD1 has a dNTPase-independent function in… (More)
DOI: 10.1016/j.celrep.2017.08.008


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