SALMONELLA TYPHI IN VIVO ACQUIRES RESISTANCE TO BOTH CHLORAMPHENICOL AND CO-TRIMOXAZOLE

@article{Datta1981SALMONELLATI,
  title={SALMONELLA TYPHI IN VIVO ACQUIRES RESISTANCE TO BOTH CHLORAMPHENICOL AND CO-TRIMOXAZOLE},
  author={Naomi Datta and Hilary Richards and C Datta},
  journal={The Lancet},
  year={1981},
  volume={317},
  pages={1181-1183}
}
Salmonella typhi in the bowel of a patient with enteric fever treated with chloramphenicol and later co-trimoxazole acquired resistance to these drugs. Chloramphenicol and sulphonamide resistances were determined by one plasmid, of IncH, whose carriage also changed the Vi phage type. Trimethoprim resistance was determined by a transposon, Tn7, carried in another plasmid, of IncI. The same resistance genes were identified in a strain of klebsiella isolated from the patient. 

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