SALL4 is a novel therapeutic target in intrahepatic cholangiocarcinoma

  title={SALL4 is a novel therapeutic target in intrahepatic cholangiocarcinoma},
  author={Gang Deng and Lei Zhu and Feizhou Huang and Wanpin Nie and Wei Huang and Hongbo Xu and Shaopeng Zheng and Zhongjie Yi and Tao Wan},
Intrahepatic cholangiocarcinoma (ICC) is the most common and deadly disease of the biliary tree due to its poor prognosis. Sal-like protein 4 (SALL4), a stem cell marker, has been identified as a potential target for aggressive hepatocellular carcinoma (HCC). In our study, 175 ICC cases with an average age of 55 years were included, and 53% (93/175) were male. And 28 adjacent non-tumor tissues were also collected. The SALL4-positive immunoreactivity was detected in a total of 102 ICC cases (58… CONTINUE READING
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Molecular pathogenesis of intrahepatic cholangiocarcinoma

  • JB Andersen
  • J Hepatobiliary Pancreat Sci
  • 2014
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