SALL4: an emerging cancer biomarker and target.

  title={SALL4: an emerging cancer biomarker and target.},
  author={Xu Zhang and Xiao Yuan and Wei Zhu and Hui Qian and Wenrong Xu},
  journal={Cancer letters},
  volume={357 1},
SALL4 is a transcription factor that plays essential roles in maintaining self-renewal and pluripotency of embryonic stem cells (ESCs). In fully differentiated cells, SALL4 expression is down-regulated or silenced. Accumulating evidence suggest that SALL4 expression is reactivated in cancer. Constitutive expression of SALL4 transgene readily induces acute… CONTINUE READING



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