SALL 4 is a key regulator of survival and apoptosis in human leukemic cells

@inproceedings{Yang2008SALL4I,
  title={SALL 4 is a key regulator of survival and apoptosis in human leukemic cells},
  author={Jianchang Yang and Li Chai and Chong Shou Gao and Taylor C. Fowles and Zaida A Alipio and Hien Q. Dang and Dan Xu and Louis M. Fink and David C. Ward and Yupo Ma},
  year={2008}
}
Increasing studies suggest that SALL4 may play vital roles in leukemogenesis and stem cell phenotypes. We have mapped the global gene targets of SALL4 using chromatin immunoprecipitation followed by microarray hybridization and identified more than 2000 highconfidence, SALL4-binding genes in the human acute promyelocytic leukemic cell line, NB4. Analysis of SALL4-binding sites reveals that genes involved in cell death, cancer, DNA replication/repair, and cell cycle were highly enriched (P < .05… CONTINUE READING

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