SAK/PLK4 Is Required for Centriole Duplication and Flagella Development

@article{BettencourtDias2005SAKPLK4IR,
  title={SAK/PLK4 Is Required for Centriole Duplication and Flagella Development},
  author={M{\'o}nica Bettencourt-Dias and Ana Rodrigues-Martins and Lori Carpenter and Maria Riparbelli and Lars Lehmann and Melanie Kaye Gatt and Nuno Baltazar do Carmo and François Balloux and Giuliano Callaini and David M Glover},
  journal={Current Biology},
  year={2005},
  volume={15},
  pages={2199-2207}
}
BACKGROUND SAK/PLK4 is a distinct member of the polo-like kinase family. SAK-/- mice die during embryogenesis, whereas SAK+/- mice develop liver and lung tumors and SAK+/- MEFs show mitotic abnormalities. However, the mechanism underlying these phenotypes is still not known. RESULTS Here, we show that downregulation of SAK in Drosophila cells, by mutation or RNAi, leads to loss of centrioles, the core structures of centrosomes. Such cells are able to undergo repeated rounds of cell division… CONTINUE READING

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