SAHA-based novel HDAC inhibitor design by core hopping method.

@article{Zang2014SAHAbasedNH,
  title={SAHA-based novel HDAC inhibitor design by core hopping method.},
  author={Lan-Lan Zang and Xue-Jiao Wang and Xiao-bo Li and Shu-Qing Wang and Wei-Ren Xu and Xian-bin Xie and Xian-Chao Cheng and Huan Ma and Run-Ling Wang},
  journal={Journal of molecular graphics \& modelling},
  year={2014},
  volume={54},
  pages={
          10-8
        }
}
The catalytic activity of the histone deacetylase (HDAC) is directly relevant to the pathogenesis of cancer, and HDAC inhibitors represented a promising strategy for cancer therapy. SAHA (suberoanilide hydroxamic acid), an effective HDAC inhibitor, is an anti-cancer agent against T-cell lymphoma. However, SAHA has adverse effects such as poor pharmacokinetic properties and severe toxicities in clinical use. In order to identify better HDAC inhibitors, a compound database was established by core… Expand
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