SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production.

@article{Cho2008SAGELS,
  title={SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production.},
  author={Minkwon Cho and Koji Ishida and Jingtao Chen and Jun Ohkawa and Wei Chen and Sahori Namiki and Ayumi Kotaki and Naoko Arai and Ken-ichi Arai and Yumiko Kamogawa-Schifter},
  journal={International immunology},
  year={2008},
  volume={20 1},
  pages={155-64}
}
Plasmacytoid dendritic cells (pDCs) link innate to acquired immune responses by producing high levels of type I IFN upon infection. In order to identify the specific genes that control pDC, we compared serial analysis of gene expression libraries from human pDCs, herpes simplex virus-stimulated pDCs and monocytes. We found that Ig-like transcript ILT7 is specifically expressed on pDC cell surfaces and is down-regulated when pDC mature in response to viral or bacterial stimulation. ILT7… CONTINUE READING

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Molecular Characterization of Human Plasmacytoid Dendritic Cells

Journal of Clinical Immunology • 2009
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