• Biology, Medicine
  • Published in
    The Onderstepoort journal of…
    1993

SAG-2 oral rabies vaccine.

@article{Schumacher1993SAG2OR,
  title={SAG-2 oral rabies vaccine.},
  author={Carolin L. Schumacher and Pierre Yves Coulon and Florence Lafay and J B{\'e}n{\'e}jean and Michel F. A. Aubert and J. Barrat and A. Aubert and Anne Flamand},
  journal={The Onderstepoort journal of veterinary research},
  year={1993},
  volume={60 4},
  pages={
          459-62
        }
}
The live modified rabies virus vaccine strain SAG-2 was selected from SADBerne in a two step process employing anti-rabies glycoprotein monoclonal antibodies. The first two nucleotides coding for the amino acid in position 333 of the rabies glycoprotein are mutated. Arginine at position 333, which is associated with rabies pathogenicity, was substituted first by lysine and then by glutamic acid. The two nucleotide differences at position 333 in SAG-2 to any of six possible arginine triplets… CONTINUE READING

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