SA4503, a novel cognitive enhancer, with σ1 receptor agonistic properties

@article{Matsuno1997SA4503AN,
  title={SA4503, a novel cognitive enhancer, with $\sigma$1 receptor agonistic properties},
  author={Kiyoshi Matsuno and Toshihiko Senda and Tetsuya Kobayashi and Kazuyoshi Okamoto and Katsuhiko Nakata and Shiro Mita},
  journal={Behavioural Brain Research},
  year={1997},
  volume={83},
  pages={221-224}
}
Regional differences of the effect of σ receptor ligands on the acetylcholine release in the rat brain
TLDR
It is found that a receptor ligands differentially regulated the acetylcholine (ACh) neurotransmission in the rat brain and was more potent than that elicited by DTG.
Involvement of the sigma 1 ( r 1 ) receptor in the anti-amnesic , but not antidepressant-like , effects of the aminotetrahydrofuran derivative ANAVEX 1-41
TLDR
ANAVEX1-41 is a potent anti-amnesic drug, acting through muscarinic and s1 receptors, and the latter component may be involved in the enhancing effects of the drug on long-term memory processes.
Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative
TLDR
The neuroprotective activity of ANAVEX2-73, its mixed cholinergic/σ1 activity, its low active dose range and its long duration of action together reinforce its therapeutic potential in Alzheimer’s disease.
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