SA1 binds directly to DNA through its unique AT-hook to promote sister chromatid cohesion at telomeres.

@article{Bisht2013SA1BD,
  title={SA1 binds directly to DNA through its unique AT-hook to promote sister chromatid cohesion at telomeres.},
  author={Kamlesh Kumar Bisht and Zharko Daniloski and Susan Smith},
  journal={Journal of cell science},
  year={2013},
  volume={126 Pt 15},
  pages={3493-503}
}
Sister chromatid cohesion relies on cohesin, a complex comprising a tri-partite ring and a peripheral subunit Scc3, which is found as two related isoforms SA1 and SA2 in vertebrates. There is a division of labor between the vertebrate cohesin complexes; SA1-cohesin is required at telomeres and SA2-cohesin at centromeres. Depletion of SA1 has dramatic consequences for telomere function and genome integrity, but the mechanism by which SA1-cohesin mediates cohesion at telomeres is not well… CONTINUE READING
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