SA 4503 attenuates cocaine-induced hyperactivity and enhances methamphetamine substitution for a cocaine discriminative stimulus.

@article{Rodvelt2011SA4A,
  title={SA 4503 attenuates cocaine-induced hyperactivity and enhances methamphetamine substitution for a cocaine discriminative stimulus.},
  author={Kelli R Rodvelt and Susan Zemyan Lever and John R. Lever and Lucas R Blount and Kuo-Hsien Fan and Dennis K. Miller},
  journal={Pharmacology, biochemistry, and behavior},
  year={2011},
  volume={97 4},
  pages={676-82}
}
Cocaine exhibits preferential (~15-fold) affinity for σ₁ over σ₂ sigma receptors, and previous research has shown an interaction of σ₁ receptor-selective ligands and cocaine's behavioral effects. The present study investigated the effect of the putative sigma receptor agonist SA 4503 (1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride) on cocaine's locomotor stimulatory and discriminative stimulus properties. At doses without intrinsic activity, SA 4503 dose-dependently… CONTINUE READING

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