S6k1 is not required for Pten-deficient neuronal hypertrophy

@article{Chalhoub2006S6k1IN,
  title={S6k1 is not required for Pten-deficient neuronal hypertrophy},
  author={Nader Chalhoub and Sara C. Kozma and S. Josephine Baker},
  journal={Brain Research},
  year={2006},
  volume={1100},
  pages={32-41}
}
The tumor suppressor PTEN (phosphatase and tensin homolog) plays a critical role in the development and maintenance of the mammalian nervous system. Effects of inherited mutation of PTEN are highly variable and include macrocephaly, Lhermitte-Duclos disease (LDD) caused by a hamartomatous enlargement of the cerebellum, ataxia, seizures and autism, in addition to cancer predisposition. In the mouse, selective inactivation of Pten in post-mitotic granule neurons of the cerebellum and dentate… CONTINUE READING
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